AMD平台这几年坚持一个AM4封装接口，理论上新老主板、处理器都可以完全兼容，只是受制于技术、非技术的多方面原因，并不会跨越太多代际。
比如最新的锐龙5000系列处理器，就只有400、500系列主板支持，包括B450、X470、A520、B550、X570五款型号。
，只不过有的是基于1.1.0.0版微代码的正式版，有的还是基于1.0.8.0系列的测试版(包括1.0.8.0/1/3)，后者还未释放全部性能。
还有一部分400系列主板暂未获得新BIOS，包括华擎的X470，映泰的B450、X470，微星的部分B450、X470。
总的来说，目前已有246款400、500系列主板确认可以支持锐龙5000系列，涵盖华硕、华擎、映泰、技嘉、微星等品牌，完整名单如下：
Prime B450M-A
Prime B450M-A II
Prime B450M-K
Prime B450-Plus
TUF B450M-Plus Gaming
TUF Gaming B450M-Plus II
TUF B450M-Pro Gaming
TUF Gaming B450M-Pro II
TUF B450M-Pro S.
TUF B450-Plus Gaming
TUF B450-Pro Gaming
ROG Strix B450-F Gaming
ROG Strix B450-F Gaming II
ROG Strix B450-E Gaming
ROG Strix B450-I Gaming
Prime X470-Pro
TUF X470-Plus Gaming
ROG Strix X470-F Gaming
ROG Strix X470-I Gaming
ROG Crosshair VII Hero
ROG Crosshair VII Hero (Wi-Fi)
Prime A520-A
Prime A520M-E
Prime A520M-K
Pro A520M-C/CSM
TUF Gaming A520M-Plus
Prime B550M-K
Prime B550M-A
Prime B550M-A (Wi-Fi)
Prime B550-Plus
TUF Gaming B550M-Plus
TUF Gaming B550M-Plus (Wi-Fi)
TUF Gaming B550-Plus
ROG Strix B550-A Gaming
ROG Strix B550-I Gaming
ROG Strix B550-F Gaming
ROG Strix B550-F Gaming (Wi-Fi)
ROG Strix B550-E Gaming
ROG Strix B550-XE Gaming (Wi-Fi)
Prime X570-P
Prime X570-Pro
Pro WS X570-ACE
TUF Gaming X570-Plus
TUF Gaming X570-Plus (Wi-Fi)
TUF Gaming X570-Pro (Wi-Fi)
ROG Strix X570-E Gaming
ROG Strix X570-F Gaming
ROG Strix X570-I Gaming
ROG Crosshair VIII Impact
ROG Crosshair VIII Hero
ROG Crosshair VIII Dark HERO
ROG Crosshair VIII Hero (Wi-Fi)
ROG Crosshair VIII Formula
B450M/ac
B450M/ac R2.0
B450M Pro4
B450M Pro4 R2.0
B450M Pro4-F
B450M Steel Legend
B450M-HDV
B450M-HDV R4.0
B450 Pro4
B450 Pro4 R2.0
B450 Steel Legend
Fatal1ty B450 Gaming K4
Fatal1ty B450 Gaming-ITX/ac
X470 D4U
X470 D4U2-2T
X470 Master SLI
X470 Master SLI/ac
Fatal1ty X470 Gaming K4
Fatal1ty X470 Gaming-ITX/ac
X470 Taichi
X470 Taichi Ultimate
A520M Pro4
A520M-HDV
A520M-HVS
A520M-ITX/ac
B550M/ac
B550M-HDV
B550M Pro4
B550M Phantom Gaming 4
B550M ITX/ac
B550M Steel Legend
B550 Pro4
B550 Extreme4
B550 Phantom Gaming 4
B550 Phantom Gaming 4/ac
B550 Phantom Gaming-ITX/ax
B550 PG Velocita
B550 Steel Legend
B550 Taichi
B550 Taichi Razer Edition
X570M Pro4
X570 Phantom Gaming 4
X570 Phantom Gaming 4 Wi-Fi ax
X570 Phantom Gaming 4S
X570 Phantom Gaming X
X570 PG Velocita
X570 Phantom Gaming-ITX/TB3
X570 Steel Legend
X570 Steel Legend Wi-Fi ax
X570 Pro4
X570 Extreme4
X570 Extreme4 Wi-Fi ax
X570 Taichi
X570 Taichi Razer Edition
X570 Creator
X570 AQUA
B450MHC
B450MH
B450NH
B450GT3
B450GT
X470 X470MH
X470NH
X470GTA
X470GTN
X470GTQ
X470GT8
A520MH
B550MH
B550GTA
B550GTQ
X570GT
X570GT8
X570GTA
B450M H
B450M S2H
B450M S2H V2
B450M Gaming
B450M DS3H
B450M DS3H V2
B450M DS3H Wi-Fi
B450M Aorus Elite
B450 Aorus M
B450 Aorus Pro
B450 Aorus Pro Wi-Fi
B450 Gaming X
B450 Aorus Elite
B450 Aorus Elite V2
B450 I Aorus Pro Wi-Fi
X470 Aorus Gaming 5 Wi-Fi
X470 Aorus Gaming 7 Wi-Fi
X470 Aorus Gaming 7 Wi-Fi-50
X470 Aorus Ultra Gaming
A520M H
A520M S2H
A520M DS3H
A520 Aorus Elite
A520I AC
B550M H
B550M S2H
B550M DS3H
B550M DS3H AC
B550M Gaming
B550 Gaming X
B550 Gaming X V2
B550M Aorus Elite
B550M Aorus Pro
B550M Aorus Pro-P
B550I Aorus Pro AX
B550 Aorus Pro
B550 Aorus Pro AC
B550 Aorus Pro AX
B550 Aorus Pro V2
B550 Aorus Elite
B550 Aorus Elite V2
B550 Aorus Elite AX
B550 Aorus Elite AX V2
B550 Aorus Master
B550 Vision D
X570 UD
X570 Gaming X
X570 Aorus Pro
X570 Aorus Pro Wi-Fi
X570 Aorus Elite
X570 Aorus Elite Wi-Fi
X570 Aorus Ultra
X570 Aorus Master
X570 Aorus Xtreme
X570 I Aorus Pro Wi-Fi
B450M-A Pro MAX
B450M Pro-VDH
B450M Pro-VDH MAX
B450M Pro-VDH V2
B450M Pro-VDH Plus
B450M Pro-M2
B450M Pro-M2 MAX
B450M Pro-M2 V2
B450M Mortar
B450M Mortar MAX
B450M Mortar Titanium
B450M Gaming Plus
B450M Bazooka
B450M Bazooka MAX Wi-Fi
B450M Bazooka V2
B450M Bazooka Plus
B450I Gaming Plus AC
B450I Gaming Plus MAX Wi-Fi
B450-A Pro
B450-A Pro MAX
B450 Tomahawk
B450 Tomahawk MAX
B450 Tomahawk MAX II
B450 Gaming Plus
B450 Gaming Plus MAX
B450 Gaming Pro Carbon AC
X470 Gaming Plus
X470 Gaming Plus MAX
X470 Gaming Pro
X470 Gaming Pro MAX
X470 Gaming Pro Carbon
X470 Gaming Pro Carbon AC
X470 Gaming M7 AC
A520M Pro
A520M-A Pro
MAG A520M Vector Wi-Fi
B550M-A Pro
B550M Pro-DASH
B550M Pro-VDH
B550M Pro-VDH Wi-Fi
B550M Pro
B550-A Pro
MAG B550M Bazooka
MAG B550M Mortar
MAG B550M Mortar Wi-Fi
MAG B550M Vector Wi-Fi
MAG B550 Tomahawk
MAG B550 torpedo
MAG B550 Gaming Plus
MPG B550 Gaming Edge Wi-Fi
MPG B550 Gaming Carbon Wi-Fi
MPG B550I Gaming Edge Wi-Fi
MPG B550I Gaming Edge MAX Wi-Fi
MEG B550 Unify
MEG B550 Unify-X
X570-A PRO
MAG X570 Tomahawk Wi-Fi
MEG X570 Ace
X570 Unify
MEG X570 Godlike
MPG X570 Gaming Plus
MPG X570 Gaming Edge Wi-Fi
MPG X570 Gaming Pro Carbon Wi-Fi
Prestige X570 Creatio